�Fibrex Medical, a biopharmaceutical company focalisation on cardiovascular and incitive diseases, proclaimed positive Phase II results for FX06, a peptide for the treatment of reperfusion injury - the damage to heart musculus that results from remedial treatment following a marrow attack. The results testament be presented at the ESC Congress today in Munich, Germany.
The Phase II clinical trial of FX06 (F.I.R.E. study) in 234 patients with acute myocardial infarcts was completed in March 2008, with data indicating a statistically significant reduction in myocardial necrosis compared to placebo following endovenous application of FX06 during reperfusion discussion . FX06 is a peptide that binds to vascular endothelial (VE) cadherin, thereby inhibiting tissue inflammation and injury as well as preserving endothelial barrier function. These personal effects are deemed to be important for the bar of the paradoxical additional damage to the heart muscle known as reperfusion injury.
"We are entranced that FX06 has demonstrated efficacy in this Phase II tryout" stated Dr. Rainer Henning, President and CEO of Fibrex Medical. "FX06 is a first base in year product and we have demonstrated that it can provide clinical benefit by preventing reperfusion injury for the brobdingnagian number of patients world Health Organization survive heart attacks each year. FX06 can clearly be expected to become an significant addition to the armamentarium of the cardiologist in the catheter lab."
"Re-establishment of roue flow either by catheter-based balloon-intervention (PCI) or by thrombolysis, is necessary and life-saving in the treatment of acute myocardial infarctions, however such interventions can lead to tissue damage due to resulting rid radicals and an intense inflammatory answer," said Dan Atar, Professor of Cardiology at the Aker University Hospital, University of Oslo, Norway, wHO is the Coordinating Investigator for the F.I.R.E. Study. "Based on the F.I.R.E. results, we believe that FX06 lavatory inhibit this inflammatory response and thus prevent reperfusion injury in patients. We predict that FX06 may become a novel treatment for STEMI patients undergoing PCI representing a major advance in acute cardiac care."
Fibrex is at present planning an ambitious development program to bring this promising new product to registration and expect to carry this program out together with a licensing partner. This program will be discussed with regulatory agencies in US and Europe subsequently this year.
About Fibrex Medical Inc.
Fibrex Medical Inc. is a in camera held troupe headquartered in Cambridge, MA, USA with operations in Vienna, Austria. The Company is developing innovative therapeutics for incisive and intensive care in cardiovascular and inflammatory conditions based on novel mechanisms of action. Fibrex Medical started trading operations in 2001, and has raised a �13 M in investments from top tier venture capital investors including Atlas Venture, Global Life Science Ventures, EMBL Ventures and Mulligan Biocapital. http://www.fibrexmedical.com
Acute Myocardial Infarction (AMI) and reperfusion injury
Acute Myocardial Infarction (AMI) clay to be the number one grounds of last in the developed reality with roughly 2.1 million young cases per year in the USA, Western Europe and Japan. Percutaneous coronary thrombosis intervention to re-establish blood flow has become the standard of care for AMI patients. While rapid reperfusion is essential to preserve myocardium, the sudden exposure of the ischemic area to blood leads to an acute rabble-rousing reaction causation additional damage. It is now well accepted that this process termed reperfusion injury limits clinical success of the intervention.
About the Phase II (F.I.R.E.) study (FX06 in Ischemia / REperfusion)
The Phase II clinical trial of FX06 (F.I.R.E. study) randomized 234 patients with acute myocardial infarcts, to FX06 or placebo, with data indicating a statistically significant reduction in myocardial gangrene following intravenous application of 400mg FX06 at the time of reperfusion. Detailed results will be presented at the ESC Congress on second September in Munich, Germany.
Magnetic resonance imaging data showed that at 5 days subsequently the treatment the necrotic zone of the infarction was significantly reduced by 58% with FX06 and the summate zone of the left ventricle moved by the ischemia was reduced by 21% (non statistically substantial). This was accompanied by a decrease of markers of muscle damage (troponin I and CK-MB). After 4 months the resulting scar was also reduced to some extent, suggesting that a reduction of reperfusion injury leads to decrease in scar formation. There were signs of clinical efficaciousness as well, since cardiac related good events were also lour in FX06 treated patients (21 vc. 29 events).
Fibrex Medical Inc.
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Friday, 5 September 2008
Tuesday, 26 August 2008
Internet�s Favorite Rappers Collaborate on Track, Give MP3 Blogs the Rest of the Week Off
1. T.I. feat. Kanye West, Lil Wayne, and Jay-Z, "Swagger Like Us"
Sneaking in just in front the closing ceremonies over the weekend, the U.S. wins a gold medal in freestyle swagger with this new M.I.A.-sampling track. [Attorney St.]
2. Dido, "Look No Further"
Dido returns with this brave tale of how she gave up her dreams of comme il faut a scientist and colonised with just now becoming a rich start star. [Punkreas]
3. Lee "Scratch" Perry, "Santa Claus"
You know you're flake when you need Andrew W.K. (wHO produced Perry's new album) to help rein in the foolishness of your songs. [Winnie Cooper]
4. Of Montreal, "Gallery Piece"
Kevin Barnes says this time he's "not pretense," and later on listening to this track (which leaked with the rest of the record album this weekend), it's surd to think that he's holding anything back. [Fuck You on Friday]
5. Mr. Oizo, "Bruce Willis Is Dead"
Mr. Oizo angles for a spot in the following Die Hard movie by giving Willis the Abe Vigoda treatment on this new runway. [Lemur Blog]
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Saturday, 16 August 2008
Claire Danes, Having Watched �Tropic Thunder,� Takes Autistic Role
Claire Danes and Temple Grandin.Photos: Getty Images, Newscom
In Tropic Thunder's most talked-about � both positively and negatively � scene, Robert Downey Jr. draws a distinction between playing an autistic character and going "full retard," as Ben Stiller's Tug Speedman did in the now-notorious Simple Jack. "Dustin Hoffman," he says. "Rain Man. Looks retarded, acts retarded. Not retarded. Autistic, sure." That HBO announced Claire Danes's biopic of autism-rights advocate Temple Grandin the week of Tropic Thunder's release makes the cable net's PR team either totally foolish or evil geniuses. Danes is a capable actress, and Grandin's story � including her work designing more humane slaughterhouses � is legitimately interesting without the requisite saccharinity usually attending such fare.
The veridical question: Will the Grandin biopic win in break the "decelerate" barrier for serious actresses? Usually leading ladies in desperate search of legitimacy and/or awards follow the Charlize Theron formula of making one's normally gorgeous self count fat,
Thursday, 7 August 2008
Translantic
Artist: Translantic
Genre(s):
Rock: Progressive
Discography:
Live In Europe
Year: 2003
Tracks: 2
S.M.P.T.
Year: 2000
Tracks: 5
Beth Orton
Monday, 30 June 2008
Bee Gees 'Could Return To Performing After Brothers Death'
One of The Bee Gees brothers, Robin Gibb, has said he would be “very open” to reforming, five years after the death of his brother Maurice.
But Robin said that he would only consider bringing the famous three piece back to the stage if Barry, the band's third brother, “feels comfortable with it".
"When or where is to be decided at a time when he says yes,” Robin told the BBC.
Robin and Maurice have only made one on stage performance together since their brother died in 2003.
At the time, they said they would no longer use the band's name but Robin, who is currently promoting his solo career, said that might change.
“It's a personal thing and we'll do it when the time is right," he said. "So it's not a no, it's just emotionally when it's right."
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Tuesday, 24 June 2008
Witnesses: Tatum Cracked Out in Court
Tatum O'Neal was just arraigned in Manhattan Criminal Court for her crack and coke bust last night -- she's facing one misdemeanor charge of criminal possession of a controlled substance.
O'Neal was released on her own recognizance and she's due back in court on July 28.
Our spies say she looked a total mess in court, wearing a gray T-shirt -- and her purple bra strap was showing. She was "clearly distressed" and even had court officers blocking the view of onlookers.
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O'Neal was released on her own recognizance and she's due back in court on July 28.
Our spies say she looked a total mess in court, wearing a gray T-shirt -- and her purple bra strap was showing. She was "clearly distressed" and even had court officers blocking the view of onlookers.
See Also
Sunday, 22 June 2008
Yes says no tour as singer stricken
LOS ANGELES (Reuters) - British progressive-rock band Yes said on Wednesday it canceled its upcoming 40th anniversary tour of North America because singer Jon Anderson has been diagnosed with acute respiratory failure.
Anderson, 63, was hospitalized last month after a severe asthma attack, and doctors have told him that he will jeopardize his health unless he rests for at least six months, according to a statement.
"I'd like everyone know how deeply disappointed I am by this turn of events," Anderson said. "I was looking forward to celebrating our music with the amazing family of Yes fans once again; but as we all know, health must come before anything else."
The tour, the band's first trek through North America since 2004, was scheduled to begin on July 12 in Quebec City, and run through August 22 in Los Angeles.
Anderson, the band's main lyricist, and bass player Chris Squire are the only original members of the group, which has undergone numerous personnel shifts since it launched to immediate critical acclaim in 1968. Its hit songs included "Roundabout," "I've Seen All Good People" and the 1983 U.S. chart-topper "Owner of a Lonely Heart."
(Reporting by Dean Goodman; Editing by Bob Tourtellotte)
Anderson, 63, was hospitalized last month after a severe asthma attack, and doctors have told him that he will jeopardize his health unless he rests for at least six months, according to a statement.
"I'd like everyone know how deeply disappointed I am by this turn of events," Anderson said. "I was looking forward to celebrating our music with the amazing family of Yes fans once again; but as we all know, health must come before anything else."
The tour, the band's first trek through North America since 2004, was scheduled to begin on July 12 in Quebec City, and run through August 22 in Los Angeles.
Anderson, the band's main lyricist, and bass player Chris Squire are the only original members of the group, which has undergone numerous personnel shifts since it launched to immediate critical acclaim in 1968. Its hit songs included "Roundabout," "I've Seen All Good People" and the 1983 U.S. chart-topper "Owner of a Lonely Heart."
(Reporting by Dean Goodman; Editing by Bob Tourtellotte)
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